期刊
ORGANIC LETTERS
卷 12, 期 7, 页码 1396-1399出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol902767b
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Fund for Innovation
- Universite de Sherbrooke
Although cycloadditions of azomethine ylides usually give mixtures of endolexo adducts, we successfully tuned the mechanistic path of a new reaction cascade to afford substituted pyrrolidines in high yields and diastereomeric purity. This was achieved by forcing the demetalation of tin- or silicon-substituted iminium ions, followed by azomethine ylide cycloaddition and nucleophilic cyclization. Structural complexity is thus built rapidly In a fully controlled one-pot reaction cascade.
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