期刊
ORGANIC LETTERS
卷 12, 期 4, 页码 680-683出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol902638w
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资金
- Organon
- EPSRC
- Engineering and Physical Sciences Research Council [EP/C00292X/1] Funding Source: researchfish
A general steroid synthesis is presented that relies on prior formation of three stereogenic centers (C8, C13, and C14) on a D ring template, followed by C- and B-ring cyclizations. The assembly of the key D ring template, achieved by a 3-component conjugate addition/alkylation process, allows introduction of structural variety as required. The method is illustrated by the total synthesis of estrone via a C-ring closing metathesis and a B-ring Heck cyclization.
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