Synthesis of 2-Indolylphosphines by Palladium-Catalyzed Annulation of 1-Alkynylphosphine Sulfides with 2-Iodoanilines

Palladium-catalyzed annulation of 1-alkynylphosphine sulfides with 2-iodoanilines followed by desulfidation affords 3-substituted 2-indolylphosphines. This annulation/desulfidation sequential protocol offers a conceptually new approach to bulky heteroarylphosphines.