期刊
ORGANIC LETTERS
卷 12, 期 22, 页码 5246-5249出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol102289g
关键词
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资金
- French Research Ministry
- Agence Nationale pour la Recherche [ANR-07-CP2D-06]
- Universite Paul Cezanne
- CNRS [UMR 6263]
The first organocatalytic enantio- and diastereoselective conjugate addition of alpha-ketoamides to nitroalkenes has been achieved using a bifunctional amino thiourea catalyst. In this new approach, the substrate amide proton plays a critical role in the formation of the Michael anti-adducts in high yields and high stereoselectivities. To illustrate the high synthetic potential of this methodology, the diastereo- and enantioselective synthesis of a hexasubstituted cyclohexane via a Michael-Michael-Henry cascade reaction is described.
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