Total Synthesis of (±)-Galanthamine via a C3-Selective Stille Coupling and IMDA Cycloaddition Cascade of 3,5-Dibromo-2-pyrone

A new efficient synthetic route to (+/-)-galanthamine was devised by using a tandem C3-selective Stifle coupling-IMDA cascade of 3,5-dibromo-2-pyrone as a key strategy.