期刊
ORGANIC LETTERS
卷 12, 期 17, 页码 3894-3897出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol101590w
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资金
- Russian foundation for basic research [10-03-00243-a]
A novel and efficient method for the synthesis of heteroannulated [1,4]benzodiazepines via an isocyanide-based multicomponent reaction is reported. The tetrazolo[1,5-a][1,4]benzodiazepines were obtained by a facile azide Ugi five-center four-component reaction (U-5C-4CR) using ketones, sodium azide, ammonium chloride, and corresponding isocyanide. The aforementioned tetrazolodiazepines represent a notable class of compounds with proven platelet aggregation inhibitory and cholecystokinin agonist activities.
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