期刊
ORGANIC LETTERS
卷 12, 期 10, 页码 2442-2445出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol100924n
关键词
-
资金
- National Institutes of Health [GM-64444]
A mild, practical, and efficient method for the synthesis of unsymmetrical o-biphenols (including o-phenol-naphthols and o-binaphthols) has been developed. Unsymmetrical bis-aryloxy silanes, which were readily prepared in a semi-one-pot fashion, underwent the Pd-catalyzed intramolecular arylation followed by a routine TBAF desilylation step to furnish valuable unsymmetrical biphenols without necessity of isolation of seven-membered intermediates. The excellent functional group tolerance allows for synthesis of a variety of functionalized o-biphenols and o-binaphthols from easily available staring materials.
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