Palladium-Catalyzed Asymmetric Synthesis of Axially Chiral Allenylsilanes and Their Application to SE2′ Chirality Transfer Reactions

Stepwise application of the Pd-catalyzed S(N)2' reaction and the desilylative S(E)2' reaction to the ambivalent 2-bromo-1-silyl-1,3-dienes provides a novel route to the highly enantioselective construction of tertiary and quaternary propargylic stereogenic centers via axially chiral allenylsilanes.