期刊
ORGANIC LETTERS
卷 12, 期 19, 页码 4240-4243出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol101576q
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资金
- Zhejiang Provincial Natural Science Foundation of China [Y4090408]
- Zhejiang Provincial Major Project of China [2007C01004-2]
- Hangzhou City Research Project [20090331N04]
- Hangzhou Normal University [YS05203121]
alpha-Amino imides can be accessed straightforwardly from tertiary amines through copper-catalyzed three-component reactions involving the direct functionalization of sp(3) C-Hs adjacent to nitrogen atoms. This reaction has demonstrated a tolerance to a wide range of functionalizations and can be performed under very mild conditions. A plausible mechanism has been proposed in which an Ugi-type cascade assembly has been included.
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