期刊
ORGANIC LETTERS
卷 12, 期 21, 页码 4800-4803出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol101947s
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资金
- National Science Foundation [CHE-0848224]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0848224] Funding Source: National Science Foundation
Mechanistic experiments, including kinetics and hydrogen/deuterium kinetic isotope effects, reveal an atypical rate-determining step in a pyridylalanine-peptide catalyzed enantioselective coupling of allenoates and N-acyl imines. Typically, acrylates participate in both the aldehyde-based Morita-Baylis-Hillman (MBH) reaction and the imine-based variant (the aza-MBH) through similar mechanisms, with proton transfer/catalyst regeneration often rate-determining. In contrast, the title reaction exhibits kinetics wherein proton transfer is kinetically silent.
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