4.8 Article

Formal [4+2] Cycloaddition of Alkoxy-Substituted Donor-Acceptor Cyclobutanes and Aldehydes Catalyzed by Yb(OTf)3

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卷 12, 期 21, 页码 4736-4738

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AMER CHEMICAL SOC
DOI: 10.1021/ol102063f

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  1. University of Western Ontario
  2. National Sciences and Engineering Research Council of Canada (NSERC)
  3. Egyptian Academy of Scientific Research and Technology

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The cycloaddition between 2-alkoxy-1,1-cyclobutane diesters and aromatic, heteroaromatic, or aliphatic aldehydes under Yb(OTf)(3) catalysis generates tetrahydropyrans in high yields with exclusive cis-stereochemistry.

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