期刊
ORGANIC LETTERS
卷 12, 期 15, 页码 3453-3455出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol101252y
关键词
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资金
- Boston University
- Department of Chemistry
- NSF [CHE-0619339, CHE-0443618]
A convergent, efficient synthesis of syringolin A has been accomplished in 13 steps from commercially available materials, Garner's aldehyde and L-valine. The unnatural 3,4-dehydrolysine fragment was prepared using successive Johnson-Claisen/Curtius rearrangement reactions. The macrolactamization and late-stage introduction of the side chain will provide convenient access to analogues of this promising proteasome Inhibitor.
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