期刊
ORGANIC LETTERS
卷 12, 期 10, 页码 2290-2293出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol100659q
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资金
- University of Illinois at Chicago
A new method for the synthesis of 2,4- and 2,3,4-substituted pyrroles in two or three steps from commercially available ketones and allyl hydroxylamine is described. An iridium-catalyzed isomerization reaction has been developed to convert O-allyl oximes to O-vinyl oximes, which undergo a facile [3,3] rearrangement to form 1,4-imino aldehyde Paal-Knorr intermediates that cyclize to afford the corresponding pyrroles. Optimization and examples of the isomerization and pyrrole formation are discussed.
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