Enantioselective Conjugate Addition of Oximes to Trisubstituted β-Nitroacrylates: An Organocatalytic Approach to β2,2-Amino Acid Derivatives

A highly enanlioselective organocatalytic intermolecular conjugate addition of oximes to beta-nitroacrylates has been developed. The highly functionalized adducts obtained are valuable precursors for asymmetric synthesis, as demonstrated by the synthesis of beta(2,2)-amino acids and oxazolidin-2-ones.