期刊
ORGANIC LETTERS
卷 12, 期 12, 页码 2830-2833出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol100938j
关键词
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资金
- NIGMS
- Sloan Foundation
- GlaxoSmithKline
- AstraZeneca
- Amgen
- ACS Division of Organic Chemistry [2008-2009]
A general strategy for the catalytic asymmetric syntheses of the bakkenolides is reported. The key bond-forming step Involves an N-heterocyclic carbene catalyzed desymmetrization of a 1,3-diketone to form three new bonds in one step with excellent enantio- and diastereoselectivity. This intramolecular reaction allows direct access to the hydrindane core of the bakkenolide family and enables a facile synthesis of these natural products.
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