期刊
ORGANIC LETTERS
卷 12, 期 16, 页码 3586-3589出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol101178u
关键词
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资金
- Spanish Government [CTQ2009-12168/BQU]
- Comunidad Autonoma de Madrid [S2009/PPQ-1634]
- Universidad Autonoma de Madrid [CCG08-UAM/PPQ-4235]
Arylacetonitriles are able to participate in organocatalytic Michael additions to alpha,beta-unsaturated aldehydes by incorporating a nitro group at the phenyl ring, which acts as a temporary activating group in a remote position and allows further transformations. The sequential protocol Michael addition/NaBH4 reduction/lactonization allows the synthesis of diastereomerically pure disubstituted lactones in high yield and optical purity.
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