Copper-Catalyzed Intramolecular N-Arylation of Quinazolinones: Facile Convergent Approach to (-)-Circumdatins H and J

A copper-catalyzed intramolecular N-arylation of a quinazolinone nucleus that furnished the central benzodiazepine core unit has been demonstrated to accomplish an efficient convergent total synthesis of (-)-circumdatins H and J.