期刊
ORGANIC LETTERS
卷 12, 期 15, 页码 3446-3449出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol1012668
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资金
- EPSRC [EP/E041302/1, EP/029841/1]
- University of York
- EPSRC [EP/E041302/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E041302/1] Funding Source: researchfish
The preparation of 3,3-disubstituted oxindoles by a formal C-H, Ar-H coupling of anilides is described. Highly efficient conditions have been Identified using catalytic (5 mol %) Cu(OAc)(2)center dot H(2)O with atmospheric oxygen as the reoxidant; no additional base is required, and the reaction can be run in toluene or mesitylene. Optimization studies are reported together with a scope and limitation investigation based on variation of the anilide precursors. The application of this methodology to prepare a key Intermediate for the total synthesis of the anticancer, analgesic oxindole alkaloid Horsfiline is also described.
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