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卷 12, 期 4, 页码 708-711出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol902722y
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- Skaggs Institute for Chemical Biology
Highly enantio- and diastereoselective organocatalytic Mannich reactions of glycine Schiff bases with N-Boc-protected imines are described. Imines were generated in situ from bench-stable alpha-amido sulfones. Catalysis mediated by a cinchona alkaloid thiourea provided optically active alpha,beta-diamino acid derivatives with up to 99% ee and near-perfect diastereoselection.
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