期刊
ORGANIC LETTERS
卷 12, 期 16, 页码 3708-3711出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol1015652
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资金
- National Institutes of Health (NIH) [R01 GM081484-01]
- National Science Foundation [CHE9709183, CHE0741968]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0741968] Funding Source: National Science Foundation
An enantioselective formal synthesis of (-)-englerin A (1) is reported. Key to the strategy is a Rh-catalyzed [4 + 3] cycloaddition reaction between furan 10 and diazo ester 11 that, following an intramolecular aldol condensation, produces the tricyclic scaffold of englerin. This strategy also provides a rapid, efficient, and stereoselective access to the biologically significant core motif of the guaiane sesquiterpenes.
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