期刊
ORGANIC LETTERS
卷 12, 期 23, 页码 5418-5421出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol1022239
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Merck Frosst Centre for Therapeutic Research
- University of Toronto
- Solvias
Catalyst-controlled asymmetric ring opening of a racemic oxabicyclic alkene leads to two readily separable regioisomeric products both in excellent ee. A cationic Rh catalyst, with added NH4BF4 to modulate reactivity, was required to obtain synthetically useful yields. The utility of each substituted aminotetralin product has been demonstrated by their conversion to different biologically relevant molecules in a highly efficient and practical manner.
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