期刊
ORGANIC LETTERS
卷 12, 期 9, 页码 1904-1907出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol100073y
关键词
-
资金
- Research Foundation - Flanders (FWO - Vlaanderen) and Ghent University (BOF)
New chiral beta-(sulfonylamino)sulfinylimidates are synthesized in high overall yield and excellent diastereomeric excess via highly anti-selective Mannich-type reactions of chiral N-tert-butanesulfinyl imidates with N-tosyl aldimines. Deprotection of the beta-(sulfonylamino)sulfinylimidates gave access to enantiopure imidate hydrochlorides in high yields, as useful intermediates for an easy transformation to new chiral beta-sulfonylamino amides upon simple heating in chloroform. Hydrolysis of the imidate hydrochlorides afforded the corresponding chiral beta-sulfonylamino esters with >98% ee as new chiral beta-amino acid derivatives.
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