期刊
ORGANIC LETTERS
卷 12, 期 10, 页码 2414-2417出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol1007789
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- MOE in Singapore [T206B3225, RG53/07]
A clean and highly efficient enantioselective addition-of alpha-isocyanoacetamides to aliphatic aldehydes catalyzed by chiral phosphoric acid in the presence of MS 5 angstrom in toluene at -40 degrees C was developed. Excellent yields (85-98%) and good to excellent enantioselectivities (up to >99% ee) were achieved.
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