Liposomal Circular Dichroism. Assignment of Remote Stereocenters in Plakinic Acids K and L from a Plakortis-Xestospongia Sponge Association

Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were Isolated from a two-sponge association of Plakortis halichondroides and Xestospongia deweerdtae. The absolute configurations of the remote dimethyl-branched stereocenters in plakinic acid K were assigned by degradation of plakinic acid K to a long-chain naphthamide and analysis by liposomal circular dichroism (L-CD) and comparison with synthetic standards.