期刊
ORGANIC LETTERS
卷 12, 期 3, 页码 584-587出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol902778y
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-
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
Total synthesis of (-)-exiguolide, the natural enantiomer, has been accomplished for the first time. The bis(tetrahydropyran) subunit was efficiently synthesized via consecutive olefin cross-metathesis/intramolecular oxa-conjugate addition/reductive etherification. Construction of the 20-membered macrocycle was achieved by Yamaguchi macrolactonization. Stereoselective introduction of the (E,Z,E)-triene side chain via Suzuki-Miyaura coupling completed the total synthesis.
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