4.8 Article

An Efficient One-Step Synthesis of Heterobiaryl Pyrazolo[3,4-b]pyridines via Indole Ring Opening

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ORGANIC LETTERS
卷 11, 期 22, 页码 5214-5217

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AMER CHEMICAL SOC
DOI: 10.1021/ol902147u

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  1. National Research Foundation of Korea (NRF)
  2. Korean Ministry of Education, Science, and Technology (MEST)
  3. National Research Foundation of Korea [2006-2004590, 과06A1501, 2009-0078236, 313-2008-2-C00505, 2006-02375, 2005-2000001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A mild one-step synthetic method to access privileged heterobiaryl pyrazolo[3,4-b]pyridines from indole-3-carboxaldehyde derivatives and a variety of aminopyrazoles has been developed. This novel method constructs heterobiaryls with the wide scope of substrate generality and excellent regioselectivity via indole ring opening.

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