期刊
ORGANIC LETTERS
卷 11, 期 1, 页码 153-156出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol8025268
关键词
-
资金
- National Natural Science Foundation of China [20525206, 20772052, 90813012, 20621091]
- Ministry of Education of China
A new class of dehydroabietic amine-substituted primary amine-thiourea bifunctional catalysts were designed and synthesized. The doubly stereocontrolled organocatalytic conjugate addition of a variety of heterocycles-bearing ketones to nitroalkenes was Investigated for the first time, affording (S)- or (R)-gamma-nitro heteroaromatic ketones with excellent enantioselectivities (up to ee >99%). Furthermore, the nearly optically pure gamma-nitro heteroaromatic ketones can be readily transformed into chiral pyrrolidine carboxylic acids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据