期刊
ORGANIC LETTERS
卷 11, 期 20, 页码 4485-4487出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9018562
关键词
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资金
- Robert A. Welch Foundation
- NIH-NIGMS [R01-GM069445-S109]
Ruthenium-catalyzed tert-prenylation of isatin 1 occurs efficiently in the absence of N-protecting groups under the conditions of C-C bond-forming transfer hydrogenation employing 1,1-dimethylallene as the prenyl donor. The prenylated adduct, 3-hydroxy-3-tert-prenyl-oxindole 2, is converted to the tertiary neopentyl chloride 3, which participates in nucleophilic substitution by way of an aza-o-xylylene intermediate to furnish adducts 4a-4l. Through tertiary neopentyl substitution, two contiguous all-carbon quaternary centers are established.
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