期刊
ORGANIC LETTERS
卷 11, 期 24, 页码 5574-5577出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9025205
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canada Research Chair
- Alberta Heritage Foundation for Medical Research (AHFMR)
An oxidatively stable analogue 3 of lacticin 3147 A2 (2), wherein the sulfur atoms are replaced with oxygens, was synthesized using solution phase peptide synthesis and sequential on-resin cyclizations. Biological evaluation suggests that oxa-lacticin A2 (3) retains independent antimicrobial activity against Gram-positive bacteria but lacks the synergistic activity with natural lacticin A1 that is characteristic of the native lacticin A2 peptide.
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