期刊
ORGANIC LETTERS
卷 11, 期 14, 页码 3100-3103出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901011c
关键词
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资金
- NIH National Center for Research Resources
- NIH [CA24487]
- NIH Kirschstein National Service Research Award [GM077943]
- NIH K99 Pathway to Independence Award [GM087533]
In Caenorhabditis elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, nonaging dauer larval stage. Here, using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer formation at higher concentrations.
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