期刊
ORGANIC LETTERS
卷 11, 期 12, 页码 2655-2658出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9006794
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资金
- Japan Society for Promotion of Science [16380142]
- Ministry of Education, Culture, Sports, Science, and Technology [16073207]
- Drugs for Neglected Diseases initiative
- All Kitasato Project Study
- Grants-in-Aid for Scientific Research [16073207, 16380142] Funding Source: KAKEN
Merobatzelladines A (1) and B (2) have been isolated from a marine sponge Monanchora sp. as antibacterial constituents. Their structures including relative stereochemistry were determined by interpretation of spectral data. The absolute stereochemistry of merobatzelladine B (2) was elucidated after introduction of the fourth ring system preinstalled with a secondary hydroxyl group to which the modified Mosher method was applied. Merobatzelladines exhibit moderate anti-infective activity against a bacterium and protozoa.
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