4.8 Article

Highly Enantioselective and Organocatalytic α-Amination of 2-Oxindoles

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ORGANIC LETTERS
卷 11, 期 17, 页码 3874-3877

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AMER CHEMICAL SOC
DOI: 10.1021/ol901405r

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资金

  1. National Natural Science Foundation of China
  2. Ministry of Science and Technology [2009ZX09501-006, 2010CB833305]
  3. Chinese Academy of Sciences

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An effective method for the asymmetric synthesis of 3-amino-2-oxindoles was developed. The tetrasubstituted chiral carbon center was generated by asymmetric amination of N-unprotected 2-oxindoles with azodicarboxylate catalyzed by commercial biscinchona alkaloids In good to excellent yields with high enantioselectivities.

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