期刊
ORGANIC LETTERS
卷 11, 期 18, 页码 4120-4123出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901592f
关键词
-
资金
- National Natural Science Foundation of China and Yunnan Province [U0832603]
- Xibu Zhiguang Joint-Scholarship
Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC50 values of 3.66 and 3.58 mM, respectively.
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