期刊
ORGANIC LETTERS
卷 11, 期 23, 页码 5422-5424出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901997k
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资金
- NIH [R37 CA44848, T32CA121938]
- UCSD Cancer Therapeutics Training Program
Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC50 = 3.6 mu M.
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