期刊
ORGANIC LETTERS
卷 11, 期 18, 页码 4056-4059出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901483x
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资金
- The Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
Diphenylprolinol silyl ether was found to be an effective organocatalyst in the enantioselective and direct Michael reaction of nitroethanol and alpha,beta-unsaturated aldehydes, affording the 1-hydroxy-trans-3,4-disubstituted tetrahydropyrans after isomerization. The generated Michael addition products are useful synthetic Intermediates, which can be converted Into chiral tetrahydropyran with a quaternary stereocenter, 3-substituted cis- and trans-prolines, and alpha-amino acid derivatives.
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