期刊
ORGANIC LETTERS
卷 11, 期 20, 页码 4600-4603出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901871y
关键词
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资金
- NIH [AI063326-01]
- Greater Milwaukee Foundation
- Burroughs Welcome Fund
- Johnson Johnson
- Alfred P. Sloan Foundation
- Anandamahidol Foundation (Thailand)
A method for the synthesis of small molecule macroarrays of N-acylated L-homoserine lactones (AHLs) is reported. A focused library of AHLs was constructed, and the macroarray platform was found to be compatible with both solution and agar-overlay assays using quorum-sensing (QS) reporter strains. Several QS antagonists were discovered and serve to showcase the macroarray as a straightforward technique for QS research.
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