4.8 Article Retracted Publication

被撤回的出版物: Enantioselective Organocatalytic Hantzsch Synthesis of Polyhydroquinolines (Retracted article. See vol. 23, pg. 3802, 2021)

期刊

ORGANIC LETTERS
卷 11, 期 14, 页码 2957-2959

出版社

AMER CHEMICAL SOC
DOI: 10.1021/ol901114f

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资金

  1. McKnight Foundation [GM008353-18]
  2. Alzheimer's Association [IIRG-07-60067]
  3. NIH [NS059690]

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The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent ee's. Through catalyst screening, we found that a BINOL-phosphoric acid allowed enantioselective synthesis of six-membered heterocycles with a variety of substitution patterns.

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