期刊
ORGANIC LETTERS
卷 11, 期 14, 页码 2957-2959出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901114f
关键词
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资金
- McKnight Foundation [GM008353-18]
- Alzheimer's Association [IIRG-07-60067]
- NIH [NS059690]
The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent ee's. Through catalyst screening, we found that a BINOL-phosphoric acid allowed enantioselective synthesis of six-membered heterocycles with a variety of substitution patterns.
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