期刊
ORGANIC LETTERS
卷 11, 期 15, 页码 3434-3436出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901288r
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资金
- National Institute of General Medical Sciences [1R01GM079644]
- KU Chemical Methodologies and Library Development Center of Excellence [P50 GM069663]
Allyl esters of 3-carboxylcoumarins undergo facile decarboxylative coupling at just 25-50 degrees C. This represents the first extension of decarboxylative C-C bond-forming reactions to the coupling of aromatics with sp(3)-hybridized electrophiles. Finally, the same concept can be applied to the sp(2)-sp(3) couplings of pyrones and flavones. Thus, a variety of biologically important heteroaromatics can be readily functionalized without the need for strong bases or stoichiometric organometallics that are typically required for more standard cross-coupling reactions.
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