Two Titanium-Catalyzed Reaction Sequences for Syntheses of Pyrroles from (E/Z)-Chloroenynes or α-Haloalkynols

Titanium-catalyzed intermolecular hydroaminations of (E/Z)-chloroenynes enabled an efficient pyrrole synthesis, which set the stage for the development of a user-friendly one-pot reaction for the regioselective preparation of fully substituted pyrroles from easily accessible alpha-haloalkynols.