期刊
ORGANIC LETTERS
卷 11, 期 12, 页码 2555-2558出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol900819u
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-
资金
- Deutsche Forschungsgemcinschaft [HI 628/6]
The enantioselective total synthesis of the jatrophane diterpene (-)-15-O-acetyl-3-O-propionylcharaciol is described. Starting from an advanced cyclopentane building block, a B-alkyl Suzuki-Miyaura cross-coupling and carbonyl addition were utilized to assemble a fully functionalized triene, and a ring-closing metathesis was then employed to construct the rigid 12-membered ring. Twenty-five years after the original report on the isolation of the natural product, our total synthesis unambiguously corroborates the original tentative structural assignment.
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