期刊
ORGANIC LETTERS
卷 11, 期 11, 页码 2333-2336出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol900708d
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资金
- WV Nano Initiative at West Virginia University
- American Chemical Society PRF
A highly efficient one-pot synthesis of substituted piperidines was developed through nitroalkene, amine, and enone condensation. The transformation was suitable for a large group of substrates, giving excellent yields and diastereoselectivity. Reactions using chiral amines revealed a chirality induction through the unusual exocyclic stereochemistry control, producing enantiomeric pure piperidines in simple steps.
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