期刊
ORGANIC LETTERS
卷 11, 期 1, 页码 29-32出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol802363x
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资金
- National Institutes of Health [NIBIB R01 EB7276, NCI R33 CA123537]
- NATIONAL CANCER INSTITUTE [R33CA123537] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB007276] Funding Source: NIH RePORTER
Novel near-infrared pyrimidine-fused pH fluorescent probes were prepared by an unusual barbiturate-mediated debenzoindolation and subsequent heteroannulation. A plausible mechanistic pathway Is proposed, and the final structures were further elucidated by 2D-NMR. All new compounds are highly fluorescent In the near-infrared region and possess excellent spectral sensitivities to environmental pH changes.
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