期刊
ORGANIC LETTERS
卷 11, 期 2, 页码 461-464出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol8025704
关键词
-
资金
- NIH [U19 CA113297, AI52218]
Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, on the basis of the appended sugar, into two distinct compound subsets.
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