期刊
ORGANIC LETTERS
卷 11, 期 2, 页码 285-288出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol802611w
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资金
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
- Ministry of Education, Science, Sports and Culture, Japan
- Japan Society for the Promotion of Science (JSPS) of Japan [19.07627]
The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.
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