期刊
ORGANIC LETTERS
卷 11, 期 21, 页码 5062-5065出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol9020546
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Suntory Institute for Bioorganic Research
- Naito Foundation
A novel cytotoxic peptide, termed bisebromoamide (1), has been isolated from the marine cyanobacterium Lyngbya sp. Its planar structure was determined by 1D and 2D NMR spectroscopy. The absolute stereostructure of 1 was determined by chemical degradation followed by chiral HPLC analysis. Bisebromoamide (1) exhibited potent protein kinase inhibition: the phosphorylation of ERK in NRK cells by PDGF-stimulation was selectively inhibited by treatment with 10-0.1 mu M of 1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据