期刊
ORGANIC LETTERS
卷 11, 期 20, 页码 4700-4703出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol902047z
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资金
- Institut de Chimie des Substances Naturelles (ICSN)
- Centre National pour la Recherche Scientifique (CNRS)
A concise total synthesis of the very promising anti proliferative macrolide (+)-neopeltolide (1) has been performed in 16 steps. The main steps of this approach are a Ru-II-catalyzed alkyne-enal coupling, a Pd-0-catalyzed desulfurative cross-coupling, and a stereoselective In-III-catalyzed propargylation. Four stereogenic centers out of six have been set thanks to substrate-controlled diastereoselective reactions with minimal reliance on protecting groups.
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