期刊
ORGANIC LETTERS
卷 11, 期 19, 页码 4402-4405出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol901755a
关键词
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资金
- NIH [GM-078145]
- Rutgers
- State University of New Jersey
A concise route to functionalized 14-membered macrolides related to erythronolide A was achieved. Key steps include the simultaneous formation of bis[allenic] substrates, efficient macrolactonization, highly stereoselective oxidation to the corresponding bis[spirodiepoxide], and nucleophilic spirodiepoxide opening. The structure and reactivity of these macrolides, and the strategy that led to their evaluation, are discussed.
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