Nanolobatolide, a New C18 Metabolite from the Formosan Soft Coral Sinularia nanolobata

Nanolobatolide (1), possessing a novel C-18 molecular structure, was isolated from the Formosan soft coral Sinularia nanolobata. The structure of 1 was established by extensive spectroscopic study and confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway of 1 was proposed. Nanolobatolide (1) has been found to possess significant anti-neuroinflammatory and neuroprotective activities.