4.8 Article

PtCl4-Catalyzed Cyclization Reaction of β-Allenols in the Presence of Indoles

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ORGANIC LETTERS
卷 11, 期 6, 页码 1213-1216

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AMER CHEMICAL SOC
DOI: 10.1021/ol802838v

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资金

  1. Major State Basic Research and Development Program [2009CB825300]
  2. National Natural Science Foundation of China [20732005]
  3. Science and Technology Commission of Shanghai Municipality [07DZ22937]

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The highly regioselective PtCl4-catalyzed reaction of indoles with beta-allenols in THF at room temperature afforded indole derivatives containing a six-membered ether ring at the 3-position in moderate isolated yields. On the basis of a D-labeling experiment, a mechanistic rationale was proposed.

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