期刊
ORGANIC LETTERS
卷 11, 期 1, 页码 57-60出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol802339w
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资金
- NIH
- National Cancer Institute
- Center for Cancer Research
- Developmental Therapeutics Program in the Division of Cancer Treatment
- Diagnosis of the National Cancer Institute
- NATIONAL CANCER INSTITUTE [ZICBC010469] Funding Source: NIH RePORTER
An extract from Phyllanthus engleri was identified in a bioinformatic analysis of NCI 60-cell natural product extract screening data that selectively Inhibited the growth of renal cancer cell lines. Bioassay-guided fractionation yielded two new gualane sesquiterpenes, englerins A (1) and B (2). Englerin A showed 1000-fold selectivity against six of eight renal cancer cell lines with GI(50) values ranging from 1-87 nM. The structures of I and 2 and their relative stereochemistry were established by spectroscopic methods,
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